Solution Properties
- Solubility - Kinetic and Equilibrium
- Log D 7.4
- Chemical stability
- Protein binding
Drug Metabolism
- Metabolic stability (microsomes/S9)
- CYP450 inhibition
Transporters
- PAMPA
- Caco-2 permeation
- PgP binding
In Vivo PK
- Bioavailability
- Plasma-brain ratio
- Tissue Distribution
- Excretion
- Analysis in CSF (Rat)