Our IDD program models are ideal for clients who are planning a comprehensive strategy with a staged process which can be executed under a Master Services Agreement.
DISCOVERY
Project Initiation Stage
(Hit Identification)
Establish progression path
- Establish screening assays
- Evaluate in-house or literature hits
Hit to Lead
Identify patentable lead compounds
- SAR development
- Establish in vivo activity with patentable leads
Lead optimization stage
Identify preclinical compounds
- Desirable PK and toxicological profile
- Patent filing
DEVELOPMENT
Preclinical Evaluation
(Non GLP)
Finalize preclinical compound
- Establish PK-PD correlation and toxicology in two species
- API process chemistry
Preclinical Evaluation
(GLP)
Study plan for IND filing
- Scale up and formulation of API
- IND dossier