Our target dossier services are aimed at providing a thorough due diligence to therapeutic targets before you embark on the long, expensive and winding road to discovering a novel drug. Our dossiers are not just a compilation of information available from the web but we provide a strategic perspective on current gaps in the therapeautic area, liabilities and drawbacks of current drugs and suggestions on differentiation over marketed drugs.
Target background
- Target name, taxonomy, gene ontology
- Isoforms/orthologs/paralogs, homology
- Structural characteristics, domains
Target biology
- Target expression profile
- Molecular function and cellular location
- Biological process in cells
- Target interactome
Target validation
- Target expression profile
- Molecular function and cellular location
- Biological process in cells
- Target interactome
Relevance in human disease
- Target associated disease
- Target associated drugs
- Genetic association studies (GWAS)
- Clinical trials data on efficacy and toxicity
- Target liabilities and risks
Pharmacology
- In vitro assays (biochemical and cellular)
- In vivo animal models
- Druggability
- Safety and toxicity, hazard overview
Medicinal chemistry
- Overview of chemotypes: Synthetic feasibility, druggability
- SAR/SPR trends
- Selection of chemotypes based on focused parameters
- Medicinal chemistry point of view
- Recommendations for acquiring IP
Competitive landscape
- Current treatment options, other marketed drugs in the target class
- Intellectual property landscape
- SWOT analysis
- Diffrentiation opportunities
Screening flow strategy
- Dashboards with KPIs to monitor target landscape